Adiponektin






Stiliserad bild av 3d-strukturen hos adiponektin.


Adiponektin är ett av flera hormoner som utsöndras från fettväv. Det har en roll i regleringen av glukosnivåer och fettsyrakatabolism i kroppen. Det påverkar även insulinkänsligheten samt aktiviteten av frikopplande proteiner och motverkar inflammation [1]. Låga nivåer av proteinet i blodet verkar vara en markör för ökad risk för metabolt syndrom, hypertoni och typ-2 diabetes [2]. På många sätt verkar det motverka effekterna av leptin.


När adiponektin utsöndrats från fettvävnaden till blodet kan det utöva sin funktion genom att binda till en av sina receptorer:


  • Adiponektinreceptor 1 (AdipoR1)


  • Adiponektinreceptor 2 (AdipoR2)

  • T-cadherin


Receptorerna finns i många olika delar av kroppen, inklusive hjärnan [3].


Utsöndring av adiponektin stimuleras av att dopamin binder till D1 i fettvävnad och fettceller.[4]


.mw-parser-output table.navbox{border:#aaa 1px solid;width:100%;margin:auto;clear:both;font-size:88%;text-align:center;padding:1px}.mw-parser-output table.navbox+table.navbox{margin-top:-1px}.mw-parser-output .navbox-title,.mw-parser-output .navbox-abovebelow,.mw-parser-output table.navbox th{text-align:center;padding-left:1em;padding-right:1em}.mw-parser-output .navbox-thlinkcolor .navbox-title a{color:inherit}.mw-parser-output .nowraplinks a,.mw-parser-output .nowraplinks .selflink{white-space:nowrap}.mw-parser-output .navbox-group{white-space:nowrap;text-align:right;font-weight:bold;padding-left:1em;padding-right:1em}.mw-parser-output .navbox,.mw-parser-output .navbox-subgroup{background:#fdfdfd}.mw-parser-output .navbox-list{border-color:#fdfdfd}.mw-parser-output .navbox-title,.mw-parser-output table.navbox th{background:#b0c4de}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background:#d0e0f5}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background:#deeafa}.mw-parser-output .navbox-even{background:#f7f7f7}.mw-parser-output .navbox-odd{background:transparent}














Noter |




  1. ^ Turer, A. T.; Scherer, P. E. (2012-06-12). ”Adiponectin: mechanistic insights and clinical implications” (på en). Diabetologia 55 (9): sid. 2319–2326. doi:10.1007/s00125-012-2598-x. ISSN 0012-186X. https://link.springer.com/article/10.1007%2Fs00125-012-2598-x. Läst 17 september 2018. 


  2. ^ Kishida, Ken; Funahashi, Tohru; Shimomura, Iichiro (2014-01). ”Adiponectin as a routine clinical biomarker”. Best Practice & Research Clinical Endocrinology & Metabolism 28 (1): sid. 119–130. doi:10.1016/j.beem.2013.08.006. ISSN 1521-690X. https://doi.org/10.1016/j.beem.2013.08.006. Läst 17 september 2018. 


  3. ^ Bloemer, Jenna; Pinky, Priyanka D.; Govindarajulu, Manoj; Hong, Hao; Judd, Robert; Amin, Rajesh H. (2018-07-29). ”Role of Adiponectin in Central Nervous System Disorders” (på en). Neural Plasticity 2018: sid. 1–15. doi:10.1155/2018/4593530. ISSN 2090-5904. PMID 30150999. PMC: PMC6087588. https://www.hindawi.com/journals/np/2018/4593530/. Läst 17 september 2018. 


  4. ^ Dana C. Borcherding et al, Dopamine Receptors in Human Adipocytes: Expression and Functions, PLoS One. 2011;6(9):e25537. Epub 2011 Sep 26




-

Popular posts from this blog

An IMO inspired problem

Image
14 4 This problem from IMO 1988 is said to be one of the most elegant ones in functional equations. Problem : The function $f$ is defined on the set of all positive integers as follows: begin{align} f(1) = 1, f(3) &= 3, f(2n) = f(n), \ f(4n+1) &= 2f(2n+1) - f(n), \ f(4n+3) &= 3 f(2n+1) - 2f(n) end{align} Find the number of $n$ with $f(n) = n, 1 leq n leq 1988$. The main idea towards the solution is realizing that these conditions stand for the fact that $f(n)$ just reverses the digits in the binary representation of the number $n$. So, essentially the solution is finding the number of binary pallindromes $leq 1988_{10}$. My question is the following : How to reformulate the problem so that $f(n)$ reverses the digits of $n$ in its ternary representation. Or even better, can we reformulate it for a
Read more

Management

Image
Management From Wikipedia, the free encyclopedia Jump to navigation Jump to search "Manager" redirects here. For other uses, see Management (disambiguation) and Manager (disambiguation). An organization chart for the United States Coast Guard shows the hierarchy of managerial roles in that organization. Business administration Management of a business Accounting Management accounting Financial accounting Financial audit Business entities Cooperative Corporation Limited liability company Partnership Sole proprietorship State-owned enterprise Corporate governance Annual general meeting Board of directors Supervisory board Advisory board Audit committee Corporate law Commercial law Constitutional documents Contract Corporate crime Corporate liability Insolvency law International trade law Mergers and acquisitions Economics Commodity Pu
Read more

Investment

Image
Investment From Wikipedia, the free encyclopedia Jump to navigation Jump to search This article is about investment in finance. For investment in macroeconomics, see Investment (macroeconomics). For other uses, see Investment (disambiguation). "Invest" redirects here. For the term in meteorology, see Invest (meteorology). This article needs additional citations for verification . Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. ( February 2017 ) (Learn how and when to remove this template message) In general, to invest is to distribute money in the expectation of some benefit in the future – for example, investment in durable goods, in real estate by the service industry, in factories for manufacturing, in product development, and in research and development. However, this article focuses specifically on investment in financial
Read more